Singlet Oxygen Detection and Imaging
- Materials and Optics
- Categories:Physics
- Language:English(Translation Services Available)
- Publication date:March,2021
- Pages:90
- Retail Price:(Unknown)
- Size:190mm×234mm
- Page Views:124
- Words:(Unknown)
- Star Ratings:
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Description
The combination of high reactivity and very long natural lifetime allows for direct optical detection of singlet oxygen and its interactions using its characteristic phosphorescence at around 1270 nm. Since this emission is very weak, optical detection was technically very challenging for a long time. Therefore, even today, most laboratories only exploit the high reactivity to observe the interaction with sensor molecules, rather than singlet oxygen emission itself. However, in recent years highly sensitive optical detection was developed, the authors being major contributors.
This book is dedicated to the detection of singlet oxygen, discussing possibilities, pitfalls and limits of the various methods with a special focus on time-resolved phosphorescence and the kinetics of singlet oxygen generation and decay including involved and related processes, discussing investigated systems with various complexity from solutions over in vitro to in vivo.
The long-standing paradigm that singlet oxygen phosphorescence is a benchmark for detection systems rather than an option for process observation is still ubiquitous and this book hopes to contribute in overcoming this still prevailing bias.
Author
Michael Pfitzner received his M.SC in physics from HU Berlin in 2013. Since then, he was working in the field of time-resolved spectroscopy with a special focus at singlet oxygen spectroscopy. He will finish his Ph.D. this year, with a focus at pushing in vivo singlet oxygen measurements toward a medical application. His special interest lies within the detection of these very weak NIR signals as well as data evaluation. In 2017, he began expanding his studies toward the combination of time-resolved pointwise measurements with steadystate camera-based detection methods at the Fujian Normal University (Fuzhou, China).
Jakob Pohl studied biophysics at the Humboldt-Universität zu Berlin and received his Master's degree in 2013. During a three-year stipendium from Deutsche Bundesstiftung Umwelt, he developed protocols for a reproducible cultivation of phototrophic biofilms under conditions of photodynamic inactivation. Those are, among others, the major topics of his Ph.D. thesis which he completed in 2019. Since his Bachelor's thesis in 2009, he has been working in the field of photodynamic therapy and photodynamic inactivation, studying the effects of photosensitization on human cancer cells and microorganisms. Since 2016 he has worked as a research associate at the Humboldt-Universität zu Berlin in the group of photobiophysics to develop protocols for qualitative analysis of PDI, photophysical characterization of antimicrobial surfaces, and the inactivation of algal biofilms.