This is the first book on X and Y chromosomal disorders to address these common but rarely diagnosed conditions. This book seeks to present the latest in research and clinical care addressing neuroimaging, the interaction between hormones, brain development, and neurodevelopmental progression. This book will primarily focus on 47, XXY (Klinefelter syndrome, or KS), 47, XYY (Jacobs' syndrome), and 47, XXX (Triple X). More variant disorders such as 48, XXXX, 48, XXXY and 49, XXXXY will be discussed. Topics of interest include neurological functioning, neuroimaging, social language, and the evolving perspectives of these XY chromosomal disorders. The effects of testosterone supplementation in males with 47, XXY will also be examined.

Carole A. Samango-Sprouse, George Washington University School of Medicine and Health Sciences
Dr. Samango-Sprouse is an associate clinical professor of pediatrics at the George Washington University and is an Adjunct Associate Professor in the Department of Human and Molecular Genetics at Florida International University. Dr. Samango-Sprouse is currently the Director of the Neurodevelopmental Diagnostic Center for Children and the Executive Director and Chief Science Officer of The Focus Foundation. She received her doctorate from George Washington University in Washington, DC and then studied neurobehavioral assessment at the Children's Hospital of Boston with Dr. Heidelise Als, a developmental psychologist and renown Harvard University scholar. She is trained in neuromotor and neurocognitive development, neurobehavioral skills and oral motor assessment for children with an emphasis on children with neurogenetic disorders. She is trained in Bobath neurodevelopmental training (NDT), and is certified in the assessment of pre-term infant behavior (APIB), the Brazelton Neonatal Assessment Scale (BNABS), and the Autism Diagnostic Observation Scale -2 (ADOS-2).

Table of Contents
Dedication
Acknowledgments
Introduction
Meiosis and Mitosis
Testosterone and 47, XXY
Endocrinological Issues and Hormonal Manipulation in Children and Men With Klinefelter Syndrome
Neurological Functioning in 47, XXY
Neuroimaging in XY Chromosomal Disorders
The Evolving Perspective on X and Y Chromosomal Disorders
Infant Development in X and Y Chromosomal Disorders /Phenotype and Developmental Progression of X and Y Chromosomal Variations
Social Language in X and Y Chromosomal Variations
Conclusions
References
Author Biographies